返回到 Finding Hidden Messages in DNA (Bioinformatics I)
University of California San Diego

Finding Hidden Messages in DNA (Bioinformatics I)

Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection.

状态:Data Analysis
状态:Biochemistry
中级课程小时

精选评论

MP

5.0评论日期:Dec 3, 2017

Nice and recommended.(The final exam was a bit tedious though, with many points repeatedly given simply for "uploading the logo" and not much creative leeway)

JN

5.0评论日期:Sep 22, 2020

Please be clear while explaining the course. it not clear what are they trying to explain and it takes a lot time for us to figure it out.

QL

5.0评论日期:Jul 26, 2017

The algorithms mentioned in this course are explained very well. But still a little bit of programming language is needed. Look forward to the advanced courses.

EE

4.0评论日期:Jun 27, 2017

A good course and introduction. Some of the computer graded homework assignments need better explanations for the desired result set, to avoid frustration.

MS

5.0评论日期:Jan 31, 2020

Excellent course. The Stepik grading could use a couple of tweaks and perhaps a bit more debugging, but it was an excellent blend of bioinformatics, molecular biology, and programming.

AA

5.0评论日期:Apr 29, 2020

Extremely helpful. This course is not limited to teaching us to use Bioinformatic Tools, it also helps us understand deeply the ways in which the tools work.

JL

5.0评论日期:Jul 29, 2018

This course is very very good. Challenging at times. It does not hold your hand at all times and sometimes requires research to solve some of the problems, but I like the community and the approach.

PS

4.0评论日期:Jul 19, 2022

The course has a good material, however I consider is not explained correctly. Sometimes it is very hard to understand each topics and you need some knowleadge related with programming.

DD

5.0评论日期:Sep 10, 2019

The material of the course is simply exquisitely presented. The concepts are clear, easy to grasp. You won't be a bioinformatician after doing this course, but you'll make the first step.

VV

4.0评论日期:Jul 4, 2024

Amazing course. Definitely a steep uphill climb, but designed to make one think deep and understand complex concepts. Worth the effort !

OO

5.0评论日期:Jul 15, 2020

I really enjoyed the course, most especially the code challenges in the honors track. Thanks to the tutors for this wonderful course!

DN

4.0评论日期:Sep 26, 2020

It was very tough and worth attempting it because I have given many numbers of attempts in all the quizzes but at every attempt, I could rectify my mistakes.

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