This course explores the transformative potential of artificial intelligence (AI) and blockchain, specifically focusing on how they intersect in the Web3 era. We'll begin by examining the evolution of the Internet—from the early days of Web1 to the emergence of Web3. You'll look at the layers of the Web3-AI stack, and some of the unique opportunities and challenges that AI faces in the Web3 era. In Module 2, we'll explore how blockchain can make Generative AI more transparent, secure, and reliable, and how Generative AI can enhance what blockchains do—from automating smart contracts to optimizing networks and creating personalized experiences. In Module 3, we'll look beyond Generative AI and explore other areas where AI and blockchain intersect, including Agentic AI, decentralized governance, and AI-driven tokenomics. Finally, in Module 4, we’ll examine some real-world use cases in healthcare, arts and media, global commerce, energy, and sustainability. You’ll see how blockchain and AI work together to improve security, transparency, and adaptability across industries, delivering benefits to both businesses and users alike.