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University of California San Diego

Molecular Evolution (Bioinformatics IV)

In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time. In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans. In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination. Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines.

状态:Graph Theory
状态:Bioinformatics
中级课程小时

精选评论

AB

4.0评论日期:Dec 4, 2016

At some point several instructors lost necessary passion to keep us focused. Otherwise it was a very informed and enjoyable presentation. Historical references are extremely important.

PO

5.0评论日期:Mar 30, 2021

Good course for improving algorithmic skills and keep learning something new

DD

5.0评论日期:Oct 23, 2019

Yet another course in this series with really high quality content. If you want to learn something about bioinformatics, you're in the right place.

RG

5.0评论日期:Jul 19, 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam

ZX

5.0评论日期:Jul 20, 2019

In depth and comprehensive coverage of the topics in genetic data analysis.

所有审阅

显示:20/20

Robert Goldberg-Alberts
5.0
评论日期:Jul 20, 2017
Pavel Oliynyk
5.0
评论日期:Mar 31, 2021
Zack Xu
5.0
评论日期:Jul 21, 2019
龔峰榆
5.0
评论日期:Oct 19, 2019
Daniel Danciu
5.0
评论日期:Oct 23, 2019
Samuel Channon-Wells
5.0
评论日期:Aug 17, 2018
Arun Prasanna
5.0
评论日期:May 9, 2017
Edgardo P. Felizmenio Jr.
5.0
评论日期:Sep 16, 2021
Yulan Wang
5.0
评论日期:Oct 2, 2016
Yasmine El Hajj
5.0
评论日期:Jul 27, 2020
Saif Alomari
5.0
评论日期:May 27, 2022
Weidong Xu
5.0
评论日期:Oct 30, 2016
­박준형 / 학생 / 컴퓨터공학부
5.0
评论日期:Sep 15, 2018
Christiane Andries
4.0
评论日期:Nov 6, 2017
Ari Belenkiy
4.0
评论日期:Dec 5, 2016
Hercules Pereira Neves
3.0
评论日期:Aug 15, 2017
Bryan Griffiths
3.0
评论日期:Aug 15, 2016
ZIHAN XU
3.0
评论日期:May 4, 2019
Ho Yin Chan
3.0
评论日期:Jul 27, 2019
Ashwin Somalinga Suresh
1.0
评论日期:Sep 14, 2023