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Pre-formulation

Pre-formulation

本课程是 Drug Hunting: The Science of Making New Medicines 专项课程的一部分

位教师：Erland Stevens, PhD

3,641 人已注册

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中级等级

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3个模块

深入了解一个主题并学习基础知识。

56 条评论

中级等级

推荐体验

8 小时完成

灵活的计划

自行安排学习进度

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作业

14 项作业

授课语言：英语（English）

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本课程是 Drug Hunting: The Science of Making New Medicines 专项课程专项课程的一部分

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该课程共有3个模块

In this course we will focus on how active compounds are developed into a formulation suitable for dosing in animal studies and early human clinical trials.  Factors such as the route of administration, enhancing the solubility of the drug substance, the crystalline form of the drug substance, drug substance vs. drug product, storage requirements, and how special requirements of the patient population play a role in the design of an ideal formulation will be covered.  Finally, some of the differences encountered when formulating a biologic vs. a small molecule will be discussed.

单元详情

Welcome, by the end of the course students will be able to: Define the concepts of formulation, drug substance, and drug product. Describe the role of pre-formulation in drug discovery and its impact on route of administration selection. List and explain the importance of physicochemical properties in drug discovery and development. Compare and contrast the pre-formulation considerations for small molecule drugs and biologics.