返回到 Genome Assembly Programming Challenge
University of California San Diego

Genome Assembly Programming Challenge

In Spring 2011, thousands of people in Germany were hospitalized with a deadly disease that started as food poisoning with bloody diarrhea and often led to kidney failure. It was the beginning of the deadliest outbreak in recent history, caused by a mysterious bacterial strain that we will refer to as E. coli X. Soon, German officials linked the outbreak to a restaurant in Lübeck, where nearly 20% of the patrons had developed bloody diarrhea in a single week. At this point, biologists knew that they were facing a previously unknown pathogen and that traditional methods would not suffice – computational biologists would be needed to assemble and analyze the genome of the newly emerged pathogen. To investigate the evolutionary origin and pathogenic potential of the outbreak strain, researchers started a crowdsourced research program. They released bacterial DNA sequencing data from one of a patient, which elicited a burst of analyses carried out by computational biologists on four continents. They even used GitHub for the project: https://github.com/ehec-outbreak-crowdsourced/BGI-data-analysis/wiki The 2011 German outbreak represented an early example of epidemiologists collaborating with computational biologists to stop an outbreak. In this online course you will follow in the footsteps of the bioinformaticians investigating the outbreak by developing a program to assemble the genome of the E. coli X from millions of overlapping substrings of the E.coli X genome.

状态:Infectious Diseases
状态:Computational Thinking
高级设置课程小时

精选评论

PO

5.0评论日期:Aug 3, 2017

Good course and final capstone project. Would recommend anyone from beginner to professional.

PA

5.0评论日期:Jul 13, 2017

Really tough and enjoyable Project. Learnt something very special.

FS

5.0评论日期:Sep 5, 2020

It's a great experience with learning a Genome Assembly.

AG

5.0评论日期:Jul 28, 2020

very challenging course, but still very good and you learn a lot

AS

5.0评论日期:Aug 4, 2018

I would like to say thank you to all who have created this course and specialization! Good material, excellent lecturers!

PB

5.0评论日期:Jul 27, 2019

May be the course would have given more hints. But a learned a lot from the projects.

SA

4.0评论日期:Aug 11, 2020

hi, this is a hard course and the videos are not sufficient. but finally i finished. thanks a lot

SH

5.0评论日期:Oct 20, 2020

Really enjoyable and also challenging specialization. I also enjoyed this capstone too. I gathered my interest in Algorithms and Bioinformatics field.

所有审阅

显示:20/62

John Berkowitz
2.0
评论日期:Jun 14, 2018
Teguh Santoso Lembono
3.0
评论日期:Nov 28, 2016
Fabrice Lacout
3.0
评论日期:Apr 28, 2018
Greg G.
5.0
评论日期:Apr 25, 2020
Henry Read
2.0
评论日期:Jul 28, 2018
Евгений Семченко
1.0
评论日期:Nov 23, 2020
Alexander Chertov
3.0
评论日期:Jun 8, 2018
Daniel C
3.0
评论日期:Dec 22, 2018
Padmakumar Nambiar
3.0
评论日期:Aug 27, 2017
AJM
2.0
评论日期:Jul 18, 2020
Jose Pablo Escobedo
5.0
评论日期:Nov 2, 2017
Tamilarasu S
5.0
评论日期:Apr 25, 2018
Joseph Gonzalez Nowak
5.0
评论日期:Sep 19, 2018
Alexandr Semuka
5.0
评论日期:Aug 5, 2018
Pavel Oliynyk
5.0
评论日期:Aug 4, 2017
Michael O
4.0
评论日期:May 31, 2017
Tamás Solymos
4.0
评论日期:Jun 8, 2019
Sabina Sloman
3.0
评论日期:Apr 23, 2017
Kfir Berger
2.0
评论日期:May 28, 2017
Bohdan Shtepan
1.0
评论日期:Feb 20, 2021