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学生对 University of California San Diego 提供的 Finding Hidden Messages in DNA (Bioinformatics I) 的评价和反馈

4.3
1,046 个评分

课程概述

Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection....

热门审阅

QL

Jul 26, 2017

The algorithms mentioned in this course are explained very well. But still a little bit of programming language is needed. Look forward to the advanced courses.

JN

Sep 22, 2020

Please be clear while explaining the course. it not clear what are they trying to explain and it takes a lot time for us to figure it out.

筛选依据:

201 - Finding Hidden Messages in DNA (Bioinformatics I) 的 225 个评论(共 265 个)

创建者 Cagdas U

Jan 4, 2019

The answers are stale. MEME tool results don't match what they expect. It takes a while to find students to review.

创建者 Hariz S

Jul 4, 2021

Please do Biology meet Programmer before doing this course. A bit leap even for biologist with some coding skill

创建者 Kenny S

Apr 11, 2021

the course is great, extermely informative and educational, just takes a lot of time to grok all the information

创建者 Максим

Mar 6, 2017

Есть недоработки, но вместе с комментариями других учащихся, можно разобраться в сути заданий

创建者 Amruth B

May 3, 2021

Good course! However, some parts of the honors track were too challenging for a biologist.

创建者 Tuấn N L

Aug 15, 2020

Some parts are written in a way that is very hard to understand, but overall good course

创建者 Barby S

Jan 19, 2022

NOT FOR BEGGINNERS!!!

Excellent material and teachers. I can't follow them

创建者 TeriLynn S

Jul 9, 2018

The two platform format is quite complex. But the material is excellent!

创建者 Jack C

Jan 5, 2020

The course was very informative, but at points it was very confusing.

创建者 Aditya B

Aug 5, 2016

Very well explained for both biologists and computer scientists.

创建者 정문필

May 7, 2020

Best lecture to dive into Bioinformatics first time!

创建者 Iqra A

Aug 2, 2020

Not made for a biologist but for a programming man.

创建者 Shiv H

Sep 28, 2018

Good Course but at times difficult to understand.

创建者 Nikhil Y

Apr 19, 2020

it was an amazing course!!

创建者 Meng Z

Mar 4, 2019

The course is great!

创建者 Raja A A

Dec 15, 2023

Full of knowledge

创建者 Vipin s k

Sep 11, 2024

good

创建者 samriti s

Jun 25, 2025

.

创建者 Shiyamaladevi R S 2

Nov 4, 2021

.

创建者 Todd T

Nov 9, 2017

E

创建者 Alejandro M H

Apr 25, 2022

I liked this course more years ago, when I agreed without the possibility of having a certificate. Today I register it to have the certificate and I am surprised how much it has changed. Many videos were removed and you practically depend on reading the material on Stepik. Perhaps the biggest problem is the lack of clarity of the pseudocodes and the disaster of having to wait for someone to review your assignment to complete the course. It is unbelievable that in 2022 that will be a limitation to obtain the certificate.

创建者 Evgeny T

Feb 9, 2017

To be completely honest, I was expecting more from this course. One big setback is that the course material does not really go into biochemical fundamentals of what is going on, and instead jumps straight into algorithms. This might work for someone with enough background in biology who needs to learn to code. I, on the other side, have already had some exposure to software development and algorithms, but when Pavel mentions gene expression and transcription I have a very vague idea what he is talking about.

创建者 Zhuoxi Y

May 3, 2021

The difficulty of this course is not at all beginners from a biologist's perspective. The difficulty of this course increases drastically from week 1 to week 2. I kindly suggest that the course coordinator to review the content as some students have pointed out that there are certain errors here and there in the stepik tool's content. Another point is that certain terminology presented in stepik are quite poorly explained.

创建者 Wesley R

Oct 11, 2020

Course was easy to follow and the explanations made sense from the instructors about half the time. The other half, the coding sections and pseudocode would be horribly confusing. The sections about random motif finding and gibbs sampling were particularly frustrating. I would say some coding experience is necessary to do well in this course in a reasonable timeframe.

创建者 Hugo A M A

Jun 11, 2020

It´s too dificult. It says that this course is for beginners, and during the course they assume that we know Python or any other programming language. I passed the first week of bioinformatics 1, but I gave up with the second week. I recommend first doing the course "Biology meets programming".