This course covers the stages of drug discovery in which promising compounds (leads) are identified, their optimal and suboptimal characteristics determined, and the suboptimal characteristics optimized to create a candidate suitable for the clinic. The course is built around a case study on the discovery of an antimalarial therapy. Assays useful for screening new compounds are outlined, examples of selection criteria for leads are discussed - such as potency, efficacy, and pharmacokinetics - and the structure activity relationships that contribute to the optimization of a lead series are considered. The phenotypic approach used by the antimalarial program will be briefly contrasted with a target-based program on a different target.
Lead Selection & Optimization
Lead Selection & Optimization
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作业
12 项作业
授课语言：英语（English）
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积累特定领域的专业知识
本课程是 Drug Hunting: The Science of Making New Medicines 专项课程 专项课程的一部分
在注册此课程时，您还会同时注册此专项课程。
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该课程共有3个模块
Welcome, by the end of the course students will be able to: Recognize malaria as a neglected tropical disease and understand its significance as an unmet medical need. Identify and describe some of the characteristics an effective small molecule therapeutic should possess, and liabilities to avoid. Describe the principles and common approaches used in defining and optimizing a lead compound's pharmacophore.
涵盖的内容
3个视频2个作业
涵盖的内容
6个视频3篇阅读材料6个作业
涵盖的内容
6个视频1篇阅读材料4个作业
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学生评论
5.0
27 条评论
- 5 stars
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EK
5
已于 Sep 3, 2024审阅
Key concepts covered in a concise and accessible format.
GS
5
已于 Nov 30, 2024审阅
It is a perfect course with ample knowledge and testing of knowledge by quizzes and discussions.
常见问题
To access the course materials, assignments and to earn a Certificate, you will need to purchase the Certificate experience when you enroll in a course. You can try a Free Trial instead, or apply for Financial Aid. The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.
Yes. In select learning programs, you can apply for financial aid or a scholarship if you can’t afford the enrollment fee. If fin aid or scholarship is available for your learning program selection, you’ll find a link to apply on the description page.
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