课程概述
This course covers the stages of drug discovery in which promising compounds (leads) are identified, their optimal and suboptimal characteristics determined, and the suboptimal characteristics optimized to create a candidate suitable for the clinic. The course is built around a case study on the discovery of an antimalarial therapy. Assays useful for screening new compounds are outlined, examples of selection criteria for leads are discussed - such as potency, efficacy, and pharmacokinetics - and the structure activity relationships that contribute to the optimization of a lead series are considered. The phenotypic approach used by the antimalarial program will be briefly contrasted with a target-based program on a different target.
Target audience: This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
热门审阅
GS
Nov 30, 2024
It is a perfect course with ample knowledge and testing of knowledge by quizzes and discussions.
EK
Sep 3, 2024
Key concepts covered in a concise and accessible format.
筛选依据：
1 - Lead Selection & Optimization 的 4 个评论（共 4 个）
创建者 Gaurang S
•Nov 30, 2024
It is a perfect course with ample knowledge and testing of knowledge by quizzes and discussions.
创建者 Elaina K
•Sep 4, 2024
Key concepts covered in a concise and accessible format.
创建者 Zhuraliyeva A A
•Jun 29, 2025
Loved the course and case studies!
创建者 jsingh017
•Dec 12, 2024
Excellent and informative