Chevron Left
返回到 Introduction to Industrial Bioprocess Development

学生对 Technical University of Denmark (DTU) 提供的 Introduction to Industrial Bioprocess Development 的评价和反馈

4.7
星
325 个评分

课程概述

Bioprocesses make use of microorganisms, animal cells, or enzymes to manufacture new products or complete a chemical transformation. Since ancient days, humans have been using microorganisms to transform biological materials for the production of alcoholic beverages and other fermented foods. Since then, bioprocesses have been developed for an enormous range of commercial products, from relatively cheap products such as organic solvents and industrial alcohol, to expensive specialty chemicals such as therapeutic proteins, antibiotics, and vaccines. Nowadays, the development of bioprocesses is an essential part of a large number of chemical, food, and pharmaceutical industries. The main purpose of the course “Introduction to Industrial Bioprocess Development” is to provide an overview of the common stages involved in this type of processes. The course is primarily aimed at students, researchers, and professionals with an interest in bioprocessing, biomanufacturing, or fermentation technology. Some knowledge of biology, biotechnology and/or biochemical engineering will be advantageous, but not mandatory. The course begins with a brief description of some basic properties of microorganisms and general aspects related to their use in bioprocesses at industrial scale. Following this, the kinetic bases for cell growth, substrate utilization and product formation during batch, continuous and fed-batch cultures are discussed. In addition, the course includes a group of lectures dedicated to some stages that precede fermentation; specifically, media formulation, sterilization, preservation of microorganisms and inoculum preparation. The main characteristics of predominant types of industrial bioreactors along with process parameters that need to be controlled in stirred tank reactors are also covered in one of the modules of the course. Since the expansion of a bioprocess from a lab scale to an industrial scale is of considerable importance, an additional lecture dedicated to this topic is presented. The last part of the course provides a general overview of downstream processing, addressing processes used for the removal of cells from the culture medium, methods for the disruption of cells, and isolation of the target bioproduct. By the end of the course, you should: # Be able to identify the fundamental difference between the two basic cell types: eukaryotic and prokaryotic cells # Distinguish the main steps of the brewing process # Identify some important steps in recombinant protein production # Define the different stages of the industrial production of bioethanol # Distinguish the main characteristics of the three fermentation modes: batch, continuous and fed-batch # Define important parameters of the continuous fermentation mode # Identify bioprocesses where fed-batch fermenters are used and for how long can a fed-batch process be run # Identify how defined and undefined fermentation media are formulated # Discuss the role that key components of culture media play in bioconversion processes # Recognize the importance in avoiding microbial contamination # Describe chemical and physical sterilization methods # Distinguish the main characteristics of common techniques of cell preservation # Recognize factors that are commonly considered to obtain an inoculum suitable for fermentation at industrial scale # Define what a bioreactor is and in which industrial bioprocesses are commonly used # Identify the main parameters that need to be controlled during microbial conversions in STRs # List relevant parameters that are considered for scale-up purposes # Define the sequential steps of downstream processing # Distinguish different methods for biomass removal or cell harvesting # Select common unit operations used for primary isolation...

热门审阅

SN

Oct 1, 2024

The topics of the course was very interesting and brush up the memory for Bioprocess Eng.

AP

Dec 24, 2023

It was a good course. Made us aware on various biotechnological processes in industrial scale.

筛选依据：

51 - Introduction to Industrial Bioprocess Development 的 68 个评论（共 68 个）

创建者 Kat M

•

Feb 7, 2024

Great introduction to bioprocessing including upstream, fermentation and downstream elements. From no experience at all I know feel I can contribute to these processes. Great lectures and slides. The only downside is the reading is not open access so I couldn't read it.

创建者 Mariángeles D

•

Aug 17, 2025

El contenido del curso es muy interesante y la información esta muy bien organizada. Quizas mejoraria las traducciones al español para las evaluaciones. No encontré algun item que me permita obtener una ayuda economica para acceder el certificado.

创建者 Carmen T T Z

•

Aug 11, 2024

Buen curso para tener los conocimiento principales sobre bioprocesos, desde la escala de laboratorio, hasta un escalado industrial.

创建者 Cristina P

•

May 1, 2025

Very simple and understandable. They are able to succefully pass on the base knowledge of how bioreactors and bioprocesses work

创建者 Akhil R P

•

Dec 25, 2023

It was a good course. Made us aware on various biotechnological processes in industrial scale.

创建者 Milad E

•

Sep 28, 2023

Es war sehr gut und nützlich, um alles, was wichtig und Grundlage ist, zu wiederholen

创建者 Mostafa E

•

Aug 29, 2023

Great course, all my hopes to work with the bioprocess department at DTU

创建者 Kshitij S B

•

Aug 12, 2024

Enzyme kinetic reactions can also be included in the course

创建者 ANIKET J 2

•

Jul 8, 2024

The visuals could have better for understanding

创建者 Kalyan K

•

Sep 24, 2023

please include specialization for this course

创建者 Yogesh C

•

Sep 13, 2023

Nice introductory course. Thank you DTU!!

创建者 Greusury R G Z

•

Mar 2, 2025

Very good and complete.

创建者 mohammad p

•

Jan 19, 2025

good concepts

创建者 Humna R

•

Aug 11, 2023

a nice course

创建者 VIDHYASANKARI N

•

Feb 16, 2024

Good

创建者 Bryan R b R

•

Dec 2, 2024

deberían tener la información (PDF), listo para poder descargar ya que algunos links tienen restriccion de acceso

创建者 prasad d

•

Jan 5, 2024

this only theoretical presentation and not included practical aspects